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KMID : 0363220180560070415
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Korean Journal of Dermatology
2018 Volume.56 No. 7 p.415 ~ p.420
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Immunohistochemical Expression of PD-L1 in Cutaneous Squamous Cell Carcinoma and Its Association with Risk of Metastasis
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You Moon-Hyung
Shin Dong-Hoon
Choi Jong-Soo
Bae Young-Kyung
Lee Jih-Min
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Abstract
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Background: Programmed cell death ligand 1 (PD-L1) plays a major role in the immune responses of a variety of cancers. Recently, several studies revealed that PD-L1 is differently expressed in some cases of non-melanoma skin cancer. The expression of PD-L1 in cutaneous squamous cell carcinoma has not yet been described in Korea.
Objective: To investigate the expression of PD-L1 in cutaneous squamous cell carcinoma and its association with variable clinicopathological factors.
Methods: We performed immunohistochemical staining of 52 cutaneous cell carcinoma cases, including 28 high-risk cases and 24 low-risk cases. Cases were selected from patients who had visited the department of dermatology of our hospital from 2001 to 2017. The expression patterns were assessed using the H-score. Cases demonstrating at least 1＋ of PD-L1 in more than 1% of tumor cells were considered positive.
Results: PD-L1 expression of tumor cells was 19.2% (10/52) for all cases, 0.0% (0/24) for the low-risk group, and 35.7% (10/28) for the high-risk group. PD-L1 positive cutaneous squamous cell carcinoma cases showed a significantly higher proportion of large tumors and tumors with deep invasion and a higher lymphatic metastasis rate when compared to PD-L1 negative cutaneous squamous cell carcinoma cases.
Conclusion: Our study shows that cutaneous squamous cell carcinoma exhibits PD-L1 expression in 19.2% of cases. PD-L1 positive tumors are associated with high-risk cases of cutaneous squamous cell carcinoma, which may help guide the choice of therapeutic strategy.
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KEYWORD
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Cutaneous squamous cell carcinoma, Metastasis, PD-1, PD-L1
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